Breast
On seeking for predictive alterations in response to biologic drugs
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Secretary
Lucia Dal Mastro
IRCCS OSP. POLICLINICO SAN MARTINO (GE)
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Clinical Coordinator
Valentina Guarneri
IOV PADOVA
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Pre Clinical Coordinator
Arcangela Denicolo
IRCCS SAN RAFFAELE MILANO
The ACC Breast Cancer Working Group primarily concentrates its efforts on obtaining predictive factors from alterations in the cancer cells to develop specific molecular therapies to establish specific preventive treatment for each patient.
The study, which involves 16 of the 23 ACC Institutes – coordinated by the WG secretary, Lucia Del Mastro, who is based at the San Martino Hospital in Genoa – focuses on a cancer subtype for which it is currently more difficult to achieve a high rate of recovery. In particular, the focus of the researchers is on the triple-negative breast cancer that tests negative to the three receptors used in the treatment of other forms of breast cancer (oestrogen, progesterone and Her2 receptors) and for which no specific treatment exists.
The route indicated by Del Mastro involves the use of an oncochip (genetic code created in the laboratory and able to identify essential anomalies in the cancer cells) to identify a panel of genes whose alterations could be responsible for drug resistance but, at the same time, predictive of response to new targeted biological treatments which have much higher efficacy and far lower toxicity.
Besides the expertise of the researchers and the clinicians that make up the Working Group, the strength of the Breast Cancer WG, as for all the other ACC Working Groups, lies in its numbers: 10,000 cases are treated every year in the 16 Institutes involved – very high when compared to the overall number of cases treated nationally. Working through a network means working faster and increasing the probability of success in researching new therapeutic solutions.
Team
- Pre-Clinics
- Clinicians
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CRO AVIANO
Barbara Belletti
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ONCOLOGICO BARI
Concetta Saponaro
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IRCCS SAN RAFFAELE MILANO
Arcangela De Nicolo
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IRCCS SAN RAFFAELE MILANO
Rosa Bernardi
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IRST MELDOLA
Sara Bravaccini
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IRCCS S.G. ROTONDO
Paola Parrella
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INT MILANO
Serena Di Cosimo
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IRCCS CANDIOLO
Caterina Marchiò
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IRCCS GEMELLI ROMA
Claudio Sette, Luca Tamagnone
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IRCCS IRE
Giovanni Blandino
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AULS-IRCCS
Moira Ragazzi
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IEO MILANO
Pier Paolo Di Fiore
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IRCCS-CROB
Raffaele Ardito
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IRCCS-CROB
Carmela Mazzoccoli
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ICS MAUGERI
Carlo Morasso
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OSP. POL. S. MARTINO GENOVA
Lucia Del Mastro
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OSP. POL. S. MARTINO GENOVA
Barbara Cardinali
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IRCCS SAN MATTEO
Marco Lucioni
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IRCCS AOU BOLOGNA
Antonio De Leo
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IRCCS AOU BOLOGNA
Angelo Gianluca Corradini
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IRCCS AOU BOLOGNA
Simona Ferrari
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IRST MELDOLA
Sara Bravaccini
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IRE ROMA
Patrizia Vici
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PASCALE NAPOLI
Michelino De Laurentiis
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INT MILANO
Claudio Vernieri
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CRO AVIANO
Fabio Puglisi
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ONCOLOGICO BARI
Francesco Giotta
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OSR MILANO
Gianpaolo Bianchini
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IRST MELDOLA
Ugo De Giorgi
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IRCCS GEMELLI ROMA
Alessandra Fabi
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CSS S.G. ROTONDO
Maria Morritti
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HUMANITAS
Rita De Sanctis
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IEO MILANO
Giovanni Corso
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IOV PADOVA
Valentina Guarneri
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IRCCS CANDIOLO
Giovanna Chilà
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OSP. POL. S. MARTINO GENOVA
Giulia Buzzatti
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ICS MAUGERI
Fabio Corsi
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SAN MATTEO
Elisa Ferraris
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IRCCS S. CUORE DON CALABRIA
Stefania Gori
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IRCCS SDN
Carlo Cavaliere
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IRCCS AOU BOLOGNA
Claudio Zamagni
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IRCCS AOU BOLOGNA
Daniela Turchetti