Glioblastoma
Liquid biopsy, a priority in the research program
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Secretary
Gaetano Finocchiaro
IRCCS SAN RAFFAELE Milano
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Clinical Coordinator
Andrea Pace
IRE Roma
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Pre Clinical Coordinator
Stefano Indracciolo
IOV Padova
Glioblastoma is the most common of malignant brain tumours – with approximately 1,500 new cases diagnosed every year in Italy. It is more common in men than in women and mainly occurs in people between 55 and 75 years old.
The Glioblastoma Working Group set up by the Alliance Against Cancer – coordinated by Gaetano Finocchiaro of the IRCCS Besta in Milan with the collaboration of the preclinical coordinator Stefano Indraccolo of the IOV and the clinical coordinator Andrea Pace of the Regina Elena in Rome – is made up of a dozen laboratories from as many IRCCSs working in neuro-oncology. The activities involve exchanging samples and sharing both the results of specific tests and cell lines originating from the neoplasm.
Glioblastoma research in ACC is mainly focused on the Glioblastoma Liquid Biopsy (GBM_LIB) project, which aims to introduce liquid biopsy into the clinical armamentarium in neuro-oncology. This general objective is divided into three more specific objectives:
- assess whether a ‘small’ panel could increase the number of informative CSF biopsies compared to 50% MSK-IMPACT (Miller et al., 2019) (WP1)
- assess whether a ‘large’ panel may be informative of the development of Tumor Mutational Burden (TMB) during alkylating chemotherapy (comparison with small panel to see if MMR mutations are always associated with elevated TMB) (WP2)
- assess whether tumour plasma (EV) contains DNA and RNA and has mutations present in the CT-DNA of CSF (WP3)
Team
- Pre-Clinical
- Clinicians
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IRCCS G. PAOLO II BARI
Amalia Azzariti
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IRE ROMA
Claudia Abbruzzese
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IRCCS SAN MARTINO GENOVA
Paolo Malatesta
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HSR MILANO
Rossella Galli
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IEO MILANO
Giuliana Pelicci
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OPBG ROMA
Mara Vinci
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HUMANITAS
Lorena Passoni
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IRCCS CANDIOLO
Carla Boccaccio
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S.G. ROTONDO
Elena Binda
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IRST MELDOLA
Anna Tesei
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POLICLINICO GEMELLI
Marco Gessi
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IRCCS GASLINI
Claudia Milanaccio
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IRST MELDOLA
Jenny Bulgarelli
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IRST MELDOLA
Daniele Calistri
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IRCCS G. PAOLO II BARI
Michele Guida
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IOV PADOVA
Giuseppe Lombardi
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HUMANITAS
Matteo Simonelli
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OPBG ROMA
Angela Mastronuzzi
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IRCCS GEMELLI ROMA
Roberto Pallini
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MONDINO PAVIA
Enrico Marchioni
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IRCCS GASLINI
Maria Luisa Garrè
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S.G. ROTONDO
Leonardo Gorgoglione
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IRCCS CANDIOLO
Marco Gatti
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CRO AVIANO
Maurizio Mascarin
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IRCCS SAN MARTINO GENOVA
Elisa Bennicelli
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IRCCS S. RAFFAELE MI
Giulia Berzero
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IRCCS S. RAFFAELE MI
Gaetano Finocchiaro
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IRE ROMA
Andrea Pace
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IRST MELDOLA
Lorena Gurrieri